A number of allegations have been written about and several local, state, and federal investigations have taken place related to the notion of the Mena Intermountain Municipal Airport as a CIA drop point in large scale cocaine trafficking beginning in the latter part of the 1980s. The topic has received some press coverage that has included allegations of awareness, participation and/or coverup involvement of figures such as future presidents Bill Clinton, George H. W. Bush, and George W. Bush, as well future Florida Governor Jeb Bush and Saline County prosecutor Dan Harmon (who was convicted of numerous felonies including drug and racketeering charges in 1997). The Mena airport was also associated with Adler Berriman (Barry) Seal, an American drug smuggler and aircraft pilot who flew covert flights for the CIA and the Medellín Cartel.
A criminal investigator from the Arkansas State Police, Russell Welch, who was assigned to investigate Mena airport claimed that he opened a letter which released electrostatically charged Anthrax spores in his face, and that he had his life saved after a prompt diagnosis by a doctor. He also claimed that later, his doctor's office was vandalized, robbed, and test results and correspondence with the CDC in Atlanta were stolen,
An investigation by the CIA's inspector general concluded that the CIA had no involvement in or knowledge of any illegal activities that may have occurred in Mena. The report said that the agency had conducted a training exercise at the airport in partnership with another Federal agency and that companies located at the airport had performed "routine aviation-related services on equipment owned by the CIA".